Alirocumab attenuated plaque inflammation and PCSK9-induced proinflammatory signalling in M1 macrophages independently of lipid lowering
Cristina Espadas, Manuel Soto‐Catalán, M. Romero-Cote, Maria E. Kavanagh, Isabel Herrero del Real, Adriana Ortega‐Hernández, Jairo Lumpuy‐Castillo, Dulcenombre Gómez‐Garré, Jesús Egido, José Tuñón, Carmen Gómez‐Guerrero, Oscar Lorenzo
This study shows alirocumab reduces plaque inflammation and PCSK9-induced proinflammatory signaling in M1 macrophages without affecting LDL-C levels.
Biomolecules · Mar 6, 2026Peer-reviewedBiochemistry