Peptide-binding groove contraction linked to the lack of T-cell response: Using complex structure and energy to identify neoantigens
Y.-P. Pang, L. R. Elsbernd, M. S. Block, S. N. Markovic
This paper identifies a structural mechanism linking peptide-binding groove contraction to T-cell response failure and introduces an atom-based method to predict immunogenicity with high accuracy.
bioRxiv · Apr 5, 2018Immunology