Author

Y.-P. Pang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Assay:protein structure· 3 Organism:human· 2 Approach:mechanistic / dynamical model· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. M. Hummel· 1 shared D. E. Jenne· 1 shared D. Emerling· 1 shared D. R. Nelson· 1 shared F. H. Darras· 1 shared G. E. Thompson· 1 shared K. G. McFerrin· 1 shared L. R. Elsbernd· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiophysics

A. M. Hummel

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Author profile →

5 papers

Recent·Most cited

How a Hemicarcerand Incarcerates Guests at Room Temperature Decoded with Modular Simulations

K. G. McFerrin, Y.-P. Pang

This paper reports molecular dynamics simulations of Octacid4, a hemicarcerand, showing how it encapsulates guests at room temperature through conformational changes.

bioRxiv · Nov 20, 2020Biophysics

Remote Activation of a Latent Epitope in an Autoantigen Decoded with Simulated B-Factors

Y.-P. Pang, M. Casal Moura, G. E. Thompson, D. R. Nelson, A. M. Hummel, D. E. Jenne, D. Emerling, W. Volkmuth, W. H. Robinson, U. Specks

The paper shows that remote mutations in PR3 can activate a latent epitope, enabling antibody binding, and suggests using B-factor analysis to design therapeutics targeting autoantigens.

bioRxiv · Aug 10, 2019Biophysics

Peptide-binding groove contraction linked to the lack of T-cell response: Using complex structure and energy to identify neoantigens

Y.-P. Pang, L. R. Elsbernd, M. S. Block, S. N. Markovic

This paper identifies a structural mechanism linking peptide-binding groove contraction to T-cell response failure and introduces an atom-based method to predict immunogenicity with high accuracy.

bioRxiv · Apr 5, 2018Immunology

How Fast Fast-Folding Proteins Fold in Silico

Y.-P. Pang

This paper shows that fast-folding proteins can now fold in silico as quickly as in experiments, improving the accuracy of folding simulations for these proteins.

bioRxiv · Aug 10, 2017Biophysics

On The Use Of The Experimentally Determined Enzyme Inhibition Constant As A Measure Of Absolute Binding Affinity

F. H. Darras, Y.-P. Pang

The paper shows that enzyme inhibition constants (Ki) can be artificially increased due to inhibitor adsorption to container surfaces or enzyme inactivation, cautioning against using Ki values without detailed assay conditions.

bioRxiv · May 31, 2017Biophysics