This study identifies a mitochondrial carrier in Blastocystis that transports glycolytic intermediates, linking cytosolic and mitochondrial glycolysis and highlighting it as a potential drug target.

bioRxiv · Nov 2, 2023 · PreprintBiochemistry

Colocalization of Cancer Associated Biomarkers on Single Extracellular Vesicles for Early Cancer Detection

D. P. Salem, L. T. Bortolin, D. Gusenleitner, J. Grosha, I. O. Zabroski, K. M. Biette, S. Banerjee, C. R. Sedlak, D. M. Byrne, B. F. Hamzeh, M. S. King, L. T. Cuoco, T. Santos-Heiman, P. A. Duff, E. S. Winn-Deen, , J. C. Sedlak

This paper develops a liquid biopsy assay that detects tumor-specific biomarkers colocalized on extracellular vesicles for early cancer detection.

bioRxiv · Feb 7, 2023Cancer Biology

Structural Insight into Mitochondrial Beta-Barrel Outer Membrane Protein Biogenesis

K. A. Diederichs, X. Ni, S. E. Rollauer, I. Botos, X. Tan, M. S. King, E. R. Kunji, J. Jiang, S. K. Buchanan

The paper reports cryoEM structures of the mitochondrial SAM complex from Myceliophthora thermophila, revealing its architecture and mechanism for substrate accommodation.

bioRxiv · Apr 9, 2020Biochemistry

Major concerns with the integrity of the mitochondrial ADP/ATP carrier in dodecyl-phosphocholine used for solution NMR studies

M. S. King, P. G. Crichton, J. R. Ruprecht, E. R. Kunji

The paper raises concerns about the integrity of the mitochondrial ADP/ATP carrier AAC3 when refolded using dodecyl-phosphocholine in NMR studies.

bioRxiv · May 25, 2018Biophysics