NMR Hydrogen Exchange and Relaxation Reveal Positions Stabilized by p53 Rescue Mutants N239Y and N235K
J. Soto, C. Moody, A. Alhoshani, M. Sanchez-Bonilla, D. Martinon, M. J. Cocco
This paper uses NMR to show that rescue mutants N235K and N239Y stabilize p53 by altering protein dynamics, with distinct effects on different regions of the DNA binding domain.
bioRxiv · Feb 26, 2021 · PreprintBiophysics