Author

M. J. Cocco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Soto· 3 shared A. Alhoshani· 1 shared C. L. Moody· 1 shared C. Moody· 1 shared D. F. Senear· 1 shared D. Martinon· 1 shared E. P. Barros· 1 shared M. Sanchez-Bonilla· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiophysics

J. Soto

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Author profile →

3 papers

Recent·Most cited

Dynamic Consequences of Specificity within the Cytidine Repressor DNA-Binding Domain

C. L. Moody, J. Soto, V. Tretyachenko-Ladokhina, D. F. Senear, M. J. Cocco

This study examines how the CytR DNA-binding domain interacts with different DNA substrates, revealing structural and dynamic changes upon specific versus nonspecific binding.

bioRxiv · Feb 28, 2021 · PreprintBiophysics

NMR Hydrogen Exchange and Relaxation Reveal Positions Stabilized by p53 Rescue Mutants N239Y and N235K

J. Soto, C. Moody, A. Alhoshani, M. Sanchez-Bonilla, D. Martinon, M. J. Cocco

This paper uses NMR to show that rescue mutants N235K and N239Y stabilize p53 by altering protein dynamics, with distinct effects on different regions of the DNA binding domain.

bioRxiv · Feb 26, 2021 · PreprintBiophysics

Markov State Models and NMR Uncover an Overlooked Allosteric Loop in p53

E. P. Barros, O. Demir, J. Soto, M. J. Cocco, R. E. Amaro

The paper uses Markov state models and NMR to study p53 mutations, revealing a previously overlooked allosteric loop involved in conformational dynamics and mutation-induced inactivation.

bioRxiv · Oct 19, 2020Biophysics