Loss-of-function mutation in human Oxidation Resistance gene 1 disrupts the spatial-temporal regulation of histone arginine methylation in early brain development
X. Lin, W. Wang, M. Yang, N. Damseh, M. M. L. d. Sousa, F. Jacob, A. Lang, E. Kristiansen, M. Pannone, M. Kissova, R. Almaas, A. Kusnierczyk, R. Siller, M. Shahrour, M. Al-Ashhab, , M. Bjoras
This study identifies a loss-of-function mutation in OXR1 causing neurodevelopmental disorders and shows its role in regulating histone arginine methylation in brain organoids.
bioRxiv · May 24, 2022 · PreprintPathology