SUPREM: an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency
Y. Ochiai, B. E. Clifton, M. L. Coz, M. Terenzio, P. Laurino
This paper engineers a non-site-specific m6A RNA methyltransferase, SUPREM, with improved efficiency, thermostability, and methylation activity compared to M.EcoGII.
bioRxiv · Aug 23, 2023Biochemistry