Author

B. E. Clifton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 5 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:bacteria (other)· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

C. J. Jackson· 4 shared P. Laurino· 3 shared J. A. Kaczmarski· 2 shared A. Aderem· 1 shared A. D. Griffiths· 1 shared A. Enders· 1 shared A. Feintuch· 1 shared A. M. Buckle· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

C. J. Jackson

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

SUPREM: an engineered non-site-specific m6A RNA methyltransferase with highly improved efficiency

Y. Ochiai, B. E. Clifton, M. L. Coz, M. Terenzio, P. Laurino

This paper engineers a non-site-specific m6A RNA methyltransferase, SUPREM, with improved efficiency, thermostability, and methylation activity compared to M.EcoGII.

bioRxiv · Aug 23, 2023Biochemistry

Ultrahigh-affinity transport proteins from ubiquitous marine bacteria reveal mechanisms and global patterns of nutrient uptake

B. E. Clifton, U. Alcolombri, C. J. Jackson, P. Laurino

The paper identifies ultrahigh-affinity transport proteins in SAR11 bacteria, revealing their molecular mechanisms and global patterns of nutrient uptake in the ocean.

bioRxiv · Feb 16, 2023Biochemistry

The role of evolutionarily metastable oligomeric states in the optimization of catalytic activity

N. J. East, B. E. Clifton, C. J. Jackson, J. A. Kaczmarski

This paper investigates how trimerization and a C-terminal extension optimized the catalytic activity of cyclohexadienyl dehydratase through evolutionarily metastable oligomeric states.

bioRxiv · Sep 13, 2022Biochemistry

Evolutionary repair reveals an unexpected role of the tRNA modification m1G37 in aminoacylation

B. E. Clifton, M. A. Fariz, G.-I. Uechi, P. Laurino

This study uses experimental evolution to show that loss of the tRNA modification m1G37 in E. coli is tolerated via compensatory mutations in the proline-tRNA ligase gene proS, revealing ProRS as a gatekeeper of translational accuracy.

Nucleic Acids Research · Nov 11, 2021Peer-reviewedBiochemistry

Darwinian properties and their trade-offs in autocatalytic RNA reaction networks

S. Ameta, S. Arsene, S. Foulon, B. Saudemont, B. E. Clifton, A. D. Griffiths, P. Nghe

The paper explores how network topology in autocatalytic RNA reaction networks affects Darwinian properties like variation, reproduction, and heredity, identifying trade-offs between these traits.

bioRxiv · May 7, 2020Evolutionary Biology

Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme

J. A. Kaczmarski, M. C. Mahawaththa, A. Feintuch, B. E. Clifton, L. A. Adams, D. Goldfarb, G. Otting, C. J. Jackson

The paper investigates how remote mutations alter conformational sampling along an evolutionary trajectory, increasing catalytic activity in an enzyme.

bioRxiv · Feb 3, 2020Biochemistry

Phospho-tuning immunity through Denisovan, modern human, and mouse TNFAIP3 gene variants

N. W. Zammit, O. M. Siggs, P. Gray, K. Horikawa, S. R. Daley, D. B. Langley, D. Cultrone, E. K. Malle, S. N. Walters, J. E. Villanueva, J. Warren, A. Russell, M. J. Cowley, V. Gayevskiy, M. E. Dinger, , M. E. Craig

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.

bioRxiv · Mar 27, 2019 · PreprintImmunology