The endolysosomal phospholipid bis(monoacylglycero)phosphate is synthesized via intra- and extracellular pathways
D. Bulfon, J. Breithofer, G. F. Grabner, N. Fawzy, A. Pirchheim, H. Wolinski, D. Kolb, L. Hartig, M. Tischitz, C. Zitta, G. Bramerdorfer, A. Lass, U. Taschler, D. Kratky, P. Greimel, R. Zimmermann
This study identifies cytosolic and secreted transacylases that synthesize bis(monoacylglycero)phosphate (BMP) independently of CLN5, correcting BMP deficiency in CLN5-deficient cells.
bioRxiv · May 28, 2024 · PreprintBiochemistry