mTORC2 couples fasting to mitochondrial fission
N. Martinez-Lopez, P. Mattar, M. Toledo, H. Bains, M. Kalyani, M. L. Aoun, M. Sharma, L. B. J. McIntyre, L. Gunther-Cummins, F. P. Macaluso, J. T. Aguilan, S. Sidoli, M. Bourdenx, R. Singh
The paper shows that mTORC2 activation during fasting promotes mitochondrial fission and respiratory function through NDRG1 phosphorylation and interaction with Cdc42.
bioRxiv · Jul 19, 2022 · PreprintCell Biology