Functionality of BRCA1 supports the survival of prostate cancer cells during the development of castration resistance
S. Sriraman, V. Virtanen, A. Kukkula, M. Toriseva, A. Rokka, A. Lumiainen, J. K. Ahlskog, G. West, M. Poutanen, P. Taimen, M. Sundvall
This study shows that BRCA1 supports prostate cancer cell survival during castration resistance by modulating mTOR signaling and NRF2-mediated antioxidant processes.
bioRxiv · Jun 19, 2024 · PreprintCancer Biology