p63 sets the threshold for induction of apoptosis using a kinetically encoded ‘doorbell-like’ mechanism
J. Gebel, M. Tuppi, A. Chaikuad, K. Hoette, L. Schulz, F. Loehr, N. Gutfreund, F. Finke, M. Schroeder, E. Henrich, J. Mezhyrova, R. Lehnert, F. Pampaloni, G. Hummer, E. H. K. Stelzer, , V. Doetsch
The paper shows that TAp63 uses a slow third phosphorylation step to set a threshold for apoptosis induction in response to DNA damage.
bioRxiv · Jun 24, 2019 · PreprintBiochemistry