Structure and function of N-acetylglucosamine kinase illuminates the catalytic mechanism of ROK kinases
S. Roy, M. V. Vega, J. R. Ames, N. Britten, K. Evans, A. Kent, M. N. Isupov, N. Harmer
The paper determines the structure of NagK from Plesiomonas shigelloides in complex with GlcNAc and ATP analogue, revealing conformational changes and a sequential random mechanism.
bioRxiv · Sep 30, 2021 · PreprintBiochemistry