Author

N. Harmer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Kent· 1 shared D. Gray· 1 shared H. S. Atkins· 1 shared J. A. Littlechild· 1 shared J. P. Adams· 1 shared J. R. Ames· 1 shared K. Evans· 1 shared M. I. Richards· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiochemistry

A. Kent

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structure and function of N-acetylglucosamine kinase illuminates the catalytic mechanism of ROK kinases

S. Roy, M. V. Vega, J. R. Ames, N. Britten, K. Evans, A. Kent, M. N. Isupov, N. Harmer

The paper determines the structure of NagK from Plesiomonas shigelloides in complex with GlcNAc and ATP analogue, revealing conformational changes and a sequential random mechanism.

bioRxiv · Sep 30, 2021 · PreprintBiochemistry

Drug screening to identify compounds to act as co-therapies for the treatment of pathogenic Burkholderia

S. Barker, S. Harding, D. Gray, M. I. Richards, H. S. Atkins, N. Harmer

The paper identifies potential co-therapies for Burkholderia pseudomallei using a high-throughput screening assay with Burkholderia thailandensis, finding chloroxine as a promising candidate.

bioRxiv · Jul 8, 2019Microbiology

Engineering a seven enzyme biotransformation using mathematical modelling and characterized enzyme parts

W. Finnigan, R. Cutlan, R. Snajdrova, J. P. Adams, J. A. Littlechild, N. Harmer

The paper models and optimizes a seven-enzyme, three-step biotransformation using a deterministic process model and genetic algorithm, validated experimentally to show reliable optimization of complex enzyme cascades.

bioRxiv · Apr 9, 2019Biochemistry