Modeling the immunological pre-adaptation of HIV-1
C. H. van Dorp, M. van Boven, R. j. De Boer
This paper models how HIV-1 evolves immunological pre-adaptation and set-point virus load (SPVL) in response to host immune pressures, finding that SPVL does not optimize population-level fitness despite high heritability.
bioRxiv · Jan 8, 2020 · PreprintEvolutionary Biology