R. J. de Boer

The paper examines how TCR repertoire diversity changes with age and highlights challenges in interpreting these changes due to confounding factors and limited sample sizes.

The paper identifies persistent, antigen-specific T cell clones in JIA joints and circulation, suggesting antigen-driven expansion of both Tregs and Teffector cells.

This study develops age-dependent normalization functions for T-lymphocyte subsets in healthy Dutch individuals from infancy to adulthood, enabling quantification of changes in disease contexts.

The paper compares the turnover rates of CMV-specific CD8+ T-cells to memory phenotype CD8+ T-cells, finding they are similar regardless of response magnitude.

The paper identifies common, abundant, and shared TCRβ rearrangements lacking a D-segment, prevalent in fetal development and persisting in the elderly.

This paper shows that a Cellular Potts Model of cell migration spontaneously reproduces the universal speed-persistence coupling without being designed for it.

The paper shows that cytotoxic T cells eliminate cancer cells through multiple sublethal interactions rather than a single lethal hit, highlighting additive cytotoxicity in vivo.

This paper models how HIV-1 evolves immunological pre-adaptation and set-point virus load (SPVL) in response to host immune pressures, finding that SPVL does not optimize population-level fitness despite high heritability.

The paper estimates the distribution of clone sizes in the human naive T-cell receptor repertoire and finds that while most clones are small, some large clones exist due to peripheral selection.

The paper shows that negative T cell selection on non-random peptides enables robust self-nonself discrimination despite incomplete silencing of self-reactive cells.

The paper explains small-world properties in FRC networks using a geographical preferential attachment model and shows lattice-likeness suffices for small-world classification.