C. elegans models of Marfan and Marfan-like Syndromes reveal trafficking defects of the type II TGFβ receptor as a potential novel disease mechanism
J. Lin, M. Vora, N. S. Kane, R. J. Gleason, R. W. Padgett
This paper investigates Marfan and Marfan-like syndromes in C. elegans, revealing that type II TGFβ receptor mutations cause mis-trafficking rather than loss of function, suggesting a novel disease mechanism.
bioRxiv · Dec 27, 2018 · PreprintCancer Biology