Structural basis for C-type inactivation in a Shaker family voltage gated K+ channel
R. Reddi, K. Matulef, E. Riederer, M. Whorton, F. Valiyaveetil
This study reports the crystal structure of a Kv1.2 channel in a C-type inactivated state, revealing structural changes at the selectivity filter that disrupt ion binding sites and propagate through the channel pore.
bioRxiv · Oct 1, 2021Biochemistry