Cross-reactive anti-hemagglutinin (HA) IgG responses are shaped by previous long-interval monovalent H5 vaccination and highly correlated with HA antigenic distance
J. Wang, D. Li, S. Perry, S. P. Hilchey, A. Wiltse, J. J. Treanor, M. Y. Sangerst, M. S. Zand
This study examines how prior H5 vaccination intervals affect anti-HA IgG responses to a boosting vaccination and finds that antibody responses correlate with antigenic distance between vaccine and assay strains.
bioRxiv · Oct 14, 2020 · PreprintImmunology