Cancer BiologybioRxiv
Adrenomedullin-CALCRL Axis Controls Relapse-Initiating Drug Tolerant Acute Myeloid Leukemia Cells
C. Larrue, N. Guiraud, P.-L. Mouchel…·J.-E. Sarry
The paper identifies the ADM-CALCRL axis as a driver of drug-tolerant AML cells that persist after chemotherapy and proposes it as a therapeutic target to prevent relapse.
DOI 10.1038/s41467-020-20717-9