Host gene expression changes induced by an HIV-1 mutant associated with delayed AIDS progression reveal potential mechanisms
Sidney T. Sithole, Joshua S. Ramsey, Macey C. Call, Brian D. Poole, Brett E Pickett, Bradford K. Berges
The paper identifies 289 differentially expressed genes in HIV-1 R77Q-infected cells compared to wild-type, revealing an apoptotic signature and failure to upregulate anti-apoptotic genes like bcl-2.
bioRxiv · Feb 18, 2026 · PreprintMicrobiology