Data Matrix Normalization and Merging Strategies Minimize Batch-specific Systemic Variation in scRNA-Seq Data
Benjamin R. Babcock, Astrid Kosters, Junkai Yang, Mackenzie L White, Eliver Ghosn
The paper evaluates batch-effect correction methods in scRNA-seq by introducing a new metric and shows that optimized normalization and merging reduce the need for correction.
bioRxiv · Aug 18, 2021 · PreprintSystems Biology