Astrid Kosters

The paper identifies a distinct B-cell lineage generated during early human lymphopoiesis that shapes antibody specificity before birth.

This study generates functional B cells from human pluripotent stem cells, recapitulating B lymphopoiesis stages and enabling plasma cell differentiation for therapeutic applications.

The paper introduces Incytr, a method for discovering cell signaling pathways from multi-omics data, demonstrating its application in disease contexts and showing its utility for drug discovery and understanding cell communication.

The paper introduces SuPERR-seq, a workflow for multi-omics single-cell data integration that improves cell-type classification and identifies novel immune cell subsets.

The paper evaluates batch-effect correction methods in scRNA-seq by introducing a new metric and shows that optimized normalization and merging reduce the need for correction.