Deciphering the limitations of immortalized hepatocyte cell lines for the study of liver cis-regulatory elements
Andrew Bellesis, Xinyi Li, Dervla Moore-Frederick, Deyuan Xu, Kara Delbridge, Junjie Ma, Gabriella Vaccaro, Buddhima Athukorala Aracchige Edward, Maddie Kellogg, Yehuda Creeger, Alexander S. Okamoto, Irene M. Kaplow
This study compares cis-regulatory elements in immortalized liver cell lines to primary liver tissue using ATAC-seq, finding significant differences in transcription factor binding and gene regulation.
bioRxiv · Jun 9, 2026 · PreprintGenomics