Alexander S. Okamoto

Evolutionary trade-offs between growth and reproduction under obesogenic conditions: sex-biased skeletal and gonadal maturation in mice

This study shows that high-fat diets during adolescence shift energy allocation in mice toward reproduction, affecting skeletal and metabolic health differently in males and females.

Deciphering the limitations of immortalized hepatocyte cell lines for the study of liver cis-regulatory elements

This study compares cis-regulatory elements in immortalized liver cell lines to primary liver tissue using ATAC-seq, finding significant differences in transcription factor binding and gene regulation.

Massively parallel functional screen identifies thousands of regulatory differences in human versus chimpanzee postcranial skeletal development

Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes

This study shows that inactivating both ADAMTS10 and ADAMTS17 in mice causes severe bone shortening and skin issues, suggesting they regulate ECM formation and chondrocyte function.

Parallel evolution at the regulatory base-pair level contributes to mammalian inter-specific differences in polygenic traits.

The paper identifies parallel evolution at the regulatory base-pair level contributing to mammalian interspecific differences in polygenic traits using SNP data.