Disinhibition of the orbitofrontal cortex biases decision making in obesity
Lauren T. Seabrook, Lindsay Naef, Corey Baimel, Allap Judge, Tyra Kenney, Madelyn Ellis, Temoor Tayyab, Mataea Armstrong, Min Qiao, Stan Floresco, Stephanie L. Borgland
This study shows that obesity reduces inhibitory neurotransmission in the lateral orbitofrontal cortex, leading to inflexible food-seeking behavior in mice.
Nature Neuroscience · Dec 15, 2022Peer-reviewedNeuroscience