Disease-specific tau polymorphs define unique protein interaction networks across proteinopathies
Nicha Puangmalai, Nemil N. Bhatt, Nopparat Suthprasertporn, Ernesto G. Miranda-Morales, Nikita Shchankin, Madison Samples, Ahmet E. Balci, Jia Yi Liew, Mauro Montalbano, Yingxin Zhao, Rakez Kayed
The paper identifies disease-specific tau polymorphs and their unique protein interaction networks in Alzheimer's, PSP, and DLB, revealing distinct molecular signatures and therapeutic targets.
bioRxiv · Sep 9, 2025 · PreprintNeuroscience