PertEval-scFM: Benchmarking Single-Cell Foundation Models for Perturbation Effect Prediction
Aaron Wenteler, Martina Occhetta, Nikhil Branson, Victor Curean, Magdalena Huebner, William Dee, William Connell, Siu Pui Chung, Alex Hawkins‐Hooker, Yasha Ektefaie, Cesar Miguel Valdez Cordova, Amaya Gallagher-Syed
This study benchmarks zero-shot single-cell foundation model embeddings for perturbation effect prediction and finds they do not consistently improve over baseline models under distribution shift.
bioRxiv · Oct 2, 2024 · PreprintBioinformatics