Author

Mahdi Khadem

Florida State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:spatial domain detection· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Jonathan H. DennisiD· 3 shared Brandon D Buck· 2 shared Hank W. BassiD· 2 shared Jane M BenoitiD· 2 shared Brooke R. DrulineriD· 1 shared Kimberlee F. KossickiD· 1 shared Lisa Boardman· 1 shared Yaroslav FedyshyniD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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3 shared papersGenomics

Jonathan H. DennisORCID

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Author profile →

3 papers

Recent·Most cited

Transient alterations in nucleosome distribution and sensitivity to nuclease define the THP-1 monocyte to macrophage transition

Jane M Benoit, Brandon D Buck, Mahdi Khadem, Hank W. Bass, Jonathan H. Dennis

The paper examines nucleosome dynamics during monocyte to macrophage differentiation, finding that nucleosome sensitivity changes dynamically while distribution remains largely static.

Journal of Leukocyte Biology · Oct 1, 2025Peer-reviewedGenomics

Dynamic nucleosome redistribution and increases innucleosome sensitivity underpin THP-1 macrophage response to LPS

Jane M Benoit, Brandon D Buck, Mahdi Khadem, Hank W. Bass, Jonathan H. Dennis

The paper shows that LPS stimulation causes transient nucleosome redistribution and increased MNase sensitivity in a subset of promoters, while most promoters show sensitivity changes uncoupled from gene expression.

Journal of Leukocyte Biology · Oct 1, 2025Peer-reviewedGenomics

Nucleosome sensitivity distinguishes colon polyps based on their transformation status

Mahdi Khadem, Kimberlee F. Kossick, Yaroslav Fedyshyn, Lisa Boardman, Jonathan H. Dennis, Brooke R. Druliner

The paper identifies genomic locations with altered nucleosome sensitivity that distinguish cancer-free from cancer-associated colon polyps and suggests their potential as biomarkers for early cancer detection.

bioRxiv · Nov 8, 2022 · PreprintMolecular Biology