Jane M Benoit

The Cistrome Response to Hypoxia in Human Umbilical Vein Endothelial Cells

The paper uses MOA-seq to map transcription factor occupancy in hypoxia-treated human endothelial cells, identifying thousands of hypoxia-responsive sites and clustering them into HIF1A-associated and independent TF groups.

Transient alterations in nucleosome distribution and sensitivity to nuclease define the THP-1 monocyte to macrophage transition

The paper examines nucleosome dynamics during monocyte to macrophage differentiation, finding that nucleosome sensitivity changes dynamically while distribution remains largely static.

Dynamic nucleosome redistribution and increases innucleosome sensitivity underpin THP-1 macrophage response to LPS

The paper shows that LPS stimulation causes transient nucleosome redistribution and increased MNase sensitivity in a subset of promoters, while most promoters show sensitivity changes uncoupled from gene expression.

Nucleosome positioning and sensitivity suggest novel functional organization of the purple sea urchin (Strongylocentrotus purpuratus) genome

The paper examines nucleosome positioning and sensitivity in the purple sea urchin genome, revealing unique patterns distinct from other eukaryotes.

SARS-CoV-2 nucleocapsid uniquely disrupts chromatin over pathophysiologically relevant gene promoters

This study shows that SARS-CoV-2 nucleocapsid protein alters chromatin structure at gene promoters linked to immune and metabolic pathways in severe COVID-19.