Sparse Phosphorylatable Residues, Tuned by Agonist Chemotype, Shapes GPCR Signaling
M. K. Borah, Sarfraz Ahmed, Mahek Agrawal, Neeraj Soni, Punita Kumari, Mithu Baidya
This study shows that GPCR signaling diversity can arise from a sparse set of phosphorylation sites rather than an extensive barcode, with ligand chemotype influencing their functional impact.
bioRxiv · Oct 14, 2026 · PreprintPharmacology & Toxicology