Conditional Sequence-Structure Integration: A Novel Approach for Precision Antibody Engineering and Affinity Optimization
Benyamin Jamialahmadi, Mahmood Chamankhah, Mohammad Kohandel, Ali Ghodsi
This paper introduces a method to design antibodies by integrating antigen structure and sequence using a protein structural encoder and antibody language model, achieving better performance than existing methods.
bioRxiv · Jul 16, 2024 · PreprintImmunology