NCLX controls hepatic mitochondrial Ca2+ extrusion and couples hormone-mediated mitochondrial Ca2+ oscillations with gluconeogenesis
Mahmoud Taha, Essam A. Assali, Tsipi Ben Kasus Nissim, Grace E. Stutzmann, Orian S. Shirihai, Michal Hershfinkel, Israel Sekler
This study identifies NCLX as the primary mitochondrial Ca2+ extruder in hepatocytes, linking hormone-mediated mitochondrial Ca2+ oscillations to gluconeogenesis.
Molecular Metabolism · Jul 1, 2024Peer-reviewedPhysiology