Disruption of the MICOS complex leads to an aberrant cristae structure and an unexpected, pronounced lifespan extension in Podospora anserina
Verena Warnsmann, Lisa‐Marie Marschall, Anja C. Meeßen, Maike Wolters, Lea Schürmanns, Marion Başoğlu, Stefan Eimer, Heinz Dieter Osiewacz
This study shows that disrupting the MICOS complex in Podospora anserina leads to altered mitochondrial structure and extended lifespan, with different subcomplexes affecting lifespan through distinct mechanisms.
Journal of Cellular Biochemistry · May 26, 2022Peer-reviewedMolecular Biology