Anti-trypanosomal activity and target validation of the M17 leucyl-aminopeptidase inhibitor DDD00057570 in Trypanosoma cruzi
Mirtha Aguado, Janaina Ferreira do Nascimento, Mayke Bezerra Alencar, Maikel Izquierdo, Jorge González‐Bacerio, Ariel Mariano Silber
This study validates the M17 leucyl-aminopeptidase as a drug target in Trypanosoma cruzi and identifies DDD00057570 as a selective inhibitor with a high selectivity index.
bioRxiv · Oct 13, 2026 · PreprintMicrobiology