Ariel Mariano Silber

This study validates the M17 leucyl-aminopeptidase as a drug target in Trypanosoma cruzi and identifies DDD00057570 as a selective inhibitor with a high selectivity index.

This study profiles tRNA modifications in different life stages of Trypanosoma cruzi and finds that hydroxywybutosine modification levels regulate metacyclogenesis.

This study shows that extracellular glutamine is critical for cell division and flagellar function in Trypanosoma brucei bloodstream forms, with its absence leading to polyploid, multiflagellated cells and proteome glutamylation changes.

This study identifies phase-specific nuclear proteome changes in Trypanosoma cruzi during the cell cycle, revealing metabolic enzymes' role in nuclear processes.

This study shows that knocking out histidine ammonia-lyase in Trypanosoma cruzi prevents histidine metabolism, affecting energy production and parasite life cycle.

This study investigates the transport and metabolic roles of serine, threonine, and glycine in Trypanosoma cruzi, showing their importance in energy metabolism and stress response.

This study investigates how branched-chain amino acids (BCAAs) affect the proteomic profile of Pro-induced differentiation in Trypanosoma cruzi, revealing metabolic changes linked to reduced infectivity.