Discovery of an unusual high number of de novo mutations in sperm of older men using duplex sequencing
Renato Salazar, Barbara Arbeithuber, Maja Ivankovic, Monika Heinzl, Sofia Moura, Ingrid Hartl, Theresa Mair, Angelika Lahnsteiner, Thomas Ebner, Omar Josef Shebl, Johannes Pröll, Irene Tiemann‐Boege
The paper uses duplex sequencing to analyze de novo mutations in sperm DNA from older and younger donors, finding higher mutation frequencies and recurrence in older donors.
Genome Research · Mar 1, 2022Peer-reviewedGenetics