Author

Makenzie Plough

Washington University in St. Louis

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Developmental Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

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Farners AmargantiD· 1 shared Sara PietroforteiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperDevelopmental Biology

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1 paper

Recent·Most cited

Developmental BiologyReproductionPeer-reviewedJan 5, 2026

✦ In-depth digest

Age-associated increased stiffness of the ovarian microenvironment impairs follicle development and oocyte quality and rapidly alters follicle gene expression

Sara Pietroforte, Makenzie Plough, Farners Amargant

Hydrogels matching aged mouse ovary stiffness (5.85 kPa vs 0.84 kPa) cut follicle survival to 6.66% to 30%, reduce estradiol up to 533-fold, and alter 135 genes within 6 hours.

32 citationstop 1%

mousebulk RNA-seq

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