TXN, a Xanthohumol Derivative, Attenuates High-Fat Diet Induced Hepatic Steatosis by Antagonizing PPARγ
Yang Zhang, Gerd Bobe, Cristobal L. Miranda, Malcolm B. Lowry, Victor L. Hsu, Christiane V. Löhr, Carmen P. Wong, Donald Β. Jump, Matthew M. Robinson, Thomas J. Sharpton, Claudia S. Maier, Jan Frederik Stevens, Adrian F. Gombart
This study shows TXN, a xanthohumol derivative, reduces hepatic steatosis in mice by antagonizing PPARγ, similar to pioglitazone.
eLife · Jun 14, 2021Peer-reviewedMolecular Biology