Thomas J. Sharpton

The paper examines the covariation of PAH exposure, gut microbiome composition, and neurobehavioral traits in a human cohort, identifying candidate microbial genera that link PAH exposure to impulsivity and attention.

This study shows that prior stressor history in zebrafish affects gut microbiome structure, gene expression, and survival when exposed to a subsequent biotic challenge.

This study develops a larval zebrafish model for anthelmintic drug discovery by validating it with emamectin benzoate and documenting the development of Pseudocapillaria tomentosa.

This paper introduces a guide scaffolding method to improve phylogenetic accuracy and enable integration of 16S amplicon datasets across variable regions.

This study examines how zebrafish gut microbiome responds to temperature and parasite infection, finding that higher temperatures reduce parasitic infection and alter microbiome dynamics.

This study investigates how developmental exposure to benzo[a]pyrene affects zebrafish behavior and gut microbiome across generations, identifying AHR2 as a key mediator of these effects.

This study identifies gut microbiota-mediated metabolites that influence intestinal helminth infection in zebrafish, highlighting potential therapeutic targets.

This study shows that TXN reduces pro-inflammatory gut microbes and alleviates adipose tissue inflammation, improving metabolic syndrome in mice.

This study shows TXN, a xanthohumol derivative, reduces hepatic steatosis in mice by antagonizing PPARγ, similar to pioglitazone.

The paper introduces a greedy trend test to detect monotonic group mean trends under a broader null hypothesis, demonstrating improved type I error control and power compared to existing methods.

This study performs a meta-analysis of gut metagenomes to identify microbiome features associated with health and disease across multiple conditions.

The paper develops a new method to analyze microbial taxonomic units and their distribution across mammalian lineages, revealing conserved and lineage-specific gut bacterial clades linked to mammalian evolution.

Metacoder is an R package that enables parsing, manipulation, and visualization of hierarchical community taxonomic data through flexible plotting and analysis functions.

This paper develops ShotMAP, a metagenome annotation pipeline, and evaluates its performance on marine and gut microbiome data, finding functional differences in Crohn's disease patients.