Long-read transcriptomic identification of synaptic adaptation to amyloid pathology in the App(NL-G-F) knock-in mouse model of the earliest phase of Alzheimer's disease
Ümran Yaman, Gareth T. Banks, Emil Karl Gustavsson, Paige Mumford, Naciye Magusali, Orjona Stella Taso, Hannah L. Macpherson, Susana Carmona, Malgorzata Murray, Rasneer Sonia Bains, Hamish Forrest, Michelle E. Stewart, Connor Scott, Tatiana V. Lipina, Zhao Cheng, , Dervis A. M. Salih
The paper uses long-read RNA-seq to study splicing changes in an Alzheimer's mouse model, identifying novel transcript isoforms and alternative splicing events in response to amyloid-beta.
bioRxiv · Aug 10, 2024 · PreprintGenetics