Endocrine therapy induces oxidative stress in ER+ breast cancer that sensitizes persister cells to ferroptosis
Steven S. Tau, Malone Friedman, Alyssa M. Roberts, Lauren R. Ferridge, Sierra A. Kleist, Lauren E. Cressey, Arminja Nadine Kettenbach, Christopher J. Shoemaker, Todd W. Miller
This study shows endocrine therapy induces oxidative stress in ER+ breast cancer cells, making them more susceptible to ferroptosis, suggesting a new therapeutic strategy.
bioRxiv · Jul 18, 2025 · PreprintCancer Biology