BiophysicsPNAS NexusPeer-reviewed
Two serial filters determine P2X7R cation selectivity, Ser342 in the central pore and lateral acidic residues at the cytoplasmic interface
F Markwárdt, Eike Christian Schön, Mihaela Raycheva…·Guenther Schmalzing
This paper identifies two sequential filters in the P2X7R channel that determine cation selectivity: a dynamic tri-serine-342 size filter and static acidic residues at the cytoplasmic interface.
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