Xenopus

A topoietic model of collective morphogenesis and compartmentalization

The paper introduces topoiesis, a mechanism where diffusion and geometry drive collective morphogenesis and survival in Xenopus embryos under stress.

Calcium and actomyosin pulses drive tricellular zipping to remodel epithelial cell-cell junctions and facilitate cell packing

The paper identifies tricellular zipping as a mechanism for epithelial junction remodeling, driven by calcium and actomyosin pulses, and shows its role in cell packing across Xenopus, mouse, and Drosophila embryos.

Single-cell transcriptomics reveals transcriptional diversity of sea cucumber perivisceral fluid coelomocytes

This study uses scRNA-seq to identify transcriptional diversity in sea cucumber coelomocytes, revealing functional roles and potential progenitor and specialized cell types.

Hybrid modeling framework for bioprocesses with minimal prior knowledge and limited data

This paper introduces a hybrid modeling framework that combines mechanistic ODEs with neural networks to model bioprocesses using minimal prior knowledge and limited data.

Ontogenetic consequences of developmental temperature in amphibians: simultaneous gains in heat tolerance and cumulative costs to stress physiology

This study examines how developmental temperature affects heat tolerance and physiological costs across life stages in Xenopus laevis, finding simultaneous gains in heat tolerance and cumulative physiological costs.

CONSERVED LIFE HISTORY PHENOTYPES AMONG HISTORICALLY ISOLATED CLADES IN THE CHIRAL LIVEBEARER FISH OF LOWER CENTRAL AMERICA

The paper examines life history traits across four clades of the chiral livebearer fish Xenophallus umbratilis to assess conservation needs and adaptive evolution.

Replication protein A prevents unregulated priming and Rad51 loading on single-stranded DNA in nuclear extracts of Xenopus eggs

This study shows that RPA prevents unregulated priming and Rad51 loading on ssDNA in Xenopus egg extracts, maintaining genome stability.

Molecular and cellular characterization of the interaction between the Rho GAP RGA-3/4 and F-actin

This study investigates how RGA-3/4 regulates F-actin structure in vivo and in vitro, showing it directly binds and bundles F-actin, providing insights into its role in cortical excitability and cytokinesis.

Zyxin and LPP differ in their sensing of strained actin filaments at tricellular junctions

This study compares Zyxin and LPP's mechanoaccumulation at tricellular junctions under tension, revealing differences in their LIM domain sensing mechanisms.

TOPBP1-Dependent DNA Damage Processing Promotes Centromere Loss in an Inviable Xenopus Hybrid

The paper shows that TOPBP1-dependent DNA damage processing leads to CENP-A loss and centromere destabilization in inviable Xenopus hybrids.

An internal scaffold supports microtubule architectural diversity in Xenopus spermatids

The paper identifies an internal scaffold in Xenopus spermatid microtubules that supports structural diversity and nuclear reshaping during spermiogenesis.

Introducing a proline in the α1 M2-M3 linker relieves a molecular brake on channel activation in α1β2γ2 GABAA receptors

This study shows introducing a proline at site 2 in the α1 M2-M3 linker of GABAARs enhances GABA-sensitivity and spontaneous activity, suggesting it relieves a molecular brake on channel activation.

A passive protein environment offsets RNA folding energetics in cells

The paper shows that proteins in cell-like environments reduce RNA folding stability by passively suppressing base pairing, altering RNA structure predictions.

Widespread circulation of West Nile and Usutu viruses in sedentary and migratory avifauna: A Two-Year Study (2024-2025) of active surveillance in South of France

This study tracks WNV and USUV circulation in French avifauna over two years, finding higher USUV prevalence and seasonal variation linked to migratory and resident bird populations.

A self-organized signaling hierarchy patterns the cortex during cell repair

The paper investigates how Rho and Cdc42 signaling zones form and polarize during cell repair in Xenopus oocytes, revealing a self-organized mechanism involving protein recruitment at signaling compartment overlaps.

Spindle scaling promotes adaptation to polyploidy

This study shows that spindle scaling enables adaptation to polyploidy by modulating microtubule dynamics and architecture across different ploidy levels.

HMCES DNA-protein cross-links promote template slippage during DNA replication

This study shows HMCES-DPC formation increases DNA template flexibility, enabling slippage and mutagenic bypass of AP sites during replication.

Reconstitution of lamin assembly on nuclear pore complex-containing membranes

The paper demonstrates that lamin-B3 can assemble into filamentous structures in Xenopus laevis egg extracts under nucleoplasm-like conditions, independent of nuclear assembly.

Sequential division of labor between PAXX and XLF drives NHEJ synaptic complex stability and maturation

The paper shows PAXX and XLF have sequential roles in stabilizing and maturing the NHEJ synaptic complex through distinct interactions.

Local fluidization of an active cytoplasmic gel partitions large cells

The paper shows that cytoplasm in early embryos behaves as a locally switchable active material, enabling long-range transport of components during cleavage.

Evolution of multicellularity and reproductive strategies in yellow-green algae (Xanthophyceae, Heterokontophyta)

This study reconstructs the evolution of multicellularity and reproductive strategies in Xanthophyceae using phylogenomic data, showing multiple transitions to multicellularity linked to changes in propagule types.

Microbiome plasticity, not gut morphology, is linked to amphibian larval performance under elevated temperatures and low food quality

This study shows that amphibian larvae's microbiome adapts to warming and poor food, improving their performance and heat tolerance, more than changes in gut structure.

Real-time analysis of pore formation by bi-component staphylococcal leukotoxins using the two-electrode voltage-clamp technique

This paper develops an electrophysiological method to study pore formation by bi-component staphylococcal leukotoxins in real-time using Xenopus oocytes, revealing receptor-dependent kinetics and a hybrid model of subunit oligomerization.

Cyclin B phosphorylation by PKA safeguards the G2-arrest in vertebrate oocytes

This study identifies Cyclin B2 as a PKA substrate that phosphorylation at S271 represses Cdk1-Cyclin B activation, maintaining G2-arrest in vertebrate oocytes.

ELAVL1 and ELAVL4 are required for Musashi-dependent translational activation

This study identifies ELAVL1 and ELAVL4 as co-regulators of MSI1-dependent translational activation in Xenopus and mammals.

Axin2L regulates planar cell polarity in Xenopus embryos

This study shows Axin2L regulates planar cell polarity in Xenopus embryos by interacting with ADIP and affecting Vangl2 and ciliogenesis.

PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function

This study shows PAK4 and Afadin cooperate to maintain epithelial integrity by promoting vertex remodeling, with PAK4 inhibition disrupting junctional continuity and barrier function.

Life Under Pressure: Dissection of Cross-Phyla Metazoan Responses to Extreme Hydrostatic Pressure Reveals Pressure-Protective Heat Shock Acclimation

This study examines how shallow-dwelling Xenopus laevis embryos respond to high hydrostatic pressure and identifies heat shock pathway activation as a conserved protective mechanism across phyla.

Magnetosensitivity of amphibian morphological pigmentation is light- and eye-dependent and consistent with the radical pair mechanism

The paper shows weak magnetic fields affect Xenopus laevis tadpole pigmentation in a light- and eye-dependent manner consistent with the radical pair mechanism.

hNav1.5α forms an antiparallel intracellular homodimer but is incorporated into the plasma membrane as a monomer

This study shows hNav1.5 forms an antiparallel intracellular homodimer but is delivered to the plasma membrane as a monomer, resolving a discrepancy between electrophysiological and biochemical findings.