The CYP27A1 - VDR Feedback Rheostat Controls Mitochondrial Protein Homeostasis and Preserves Hippocampal - Striatal Network Integrity to rescue Cognitive impairment in HD condition
Vaishali Kumar, Pradeep Kodam, Chaitanya Kunja, Gayatri Brahmandam, Shreya N Balasubramanyam, Shashikant Patel, Manjari Skv, Sumana Chakravarty, Amartya Sanyal, Pragya Komal, Shuvadeep Maity
This study identifies a VD-CYP27A1 feedback loop that improves mitochondrial function and rescues cognitive deficits in HD models.
bioRxiv · Jun 22, 2026 · PreprintNeuroscience