Development and fit for purpose validation of a quantitative LC-MS/MS method for heparan sulfate in cerebrospinal fluid as a biomarker for mucopolysaccharidosis type IIIA
Cory E. Bystrom, Kevin Douglass, Manju Gupta
The paper develops and validates a quantitative LC-MS/MS method for measuring heparan sulfate in CSF as a biomarker for MPS IIIA, showing high accuracy and reproducibility.
medRxiv · Mar 30, 2026 · PreprintGenetic & Genomic Medicine