Manuel Hertwig

Chemical proteomics suggests sofosbuvir is metabolically attached to proteins through a UMPylation-like pathway.

The paper identifies 120 proteins modified by sofosbuvir through a UMPylation-like pathway using chemical proteomics.

Activity-based chemical proteomics uncovers unexpected covalent targets of E64d and reveals a role for cysteine cathepsins in PLD3 proteostasis

This study identifies cysteine cathepsins as proteases responsible for PLD3 degradation in neurons and reveals E64d's selectivity for these targets.