Pavel Kielkowski

The paper identifies 120 proteins modified by sofosbuvir through a UMPylation-like pathway using chemical proteomics.

The paper describes a chemical proteomics workflow that reduces protein input and improves sensitivity for profiling post-translational modifications.

This study identifies cysteine cathepsins as proteases responsible for PLD3 degradation in neurons and reveals E64d's selectivity for these targets.

The paper identifies CEM198 as a TTL binder through chemoproteomics, showing it disrupts microtubule dynamics via dual mechanisms in different cell lines.

This study evaluates gene supplementation of MYO7A via dual AAVs and CRISPR/Cas activation of Myo7b in animal models and human retinal organoids to treat Usher syndrome 1B.

This study shows that FICD-mediated AMPylation contributes to Parkinson's disease by promoting α-synuclein aggregation and protein dyshomeostasis in dopaminergic neurons.

The paper introduces a cysteine-reactive chloroalkane probe for HaloTag ligation, enabling efficient and specific chemical proteomics analysis.

This paper identifies two histidines in AdiY that act as pH sensors, triggering conformational changes that activate acid resistance genes in E. coli.

This study identifies AMPylation as a key regulator of PLD3 processing and catalytic activity, showing its role in neurodegenerative diseases like Parkinson's.

This study identifies EfpL as a ribosome rescue factor that senses cellular metabolic state, complementing EF-P in proline-containing sequence translation.

The paper investigates how extracellular vesicles (EVs) mediate developmental cues during brain development and disease, finding altered EV composition and function in neurodevelopmental disorders.