The molecular pathogenesis of superoxide dismutase 1-linked ALS is promoted by low oxygen tension
Isil Keskin, Elin Forsgren, Manuela Lehmann, Peter Munch Andersen, Thomas Brännström, Dale J. Lange, Matthis Synofzik, Ulrika Nordström, Per Zetterström, Stefan L. Marklund, Jonathan D. Gilthorpe
This study shows that low oxygen tension promotes SOD1 misfolding and aggregation in ALS-related cells, linking oxygen levels to disease pathogenesis.
Acta Neuropathologica · Mar 12, 2019Peer-reviewedNeuroscience